Morbidity of total pancreatectomy with islet cell auto-transplantation compared to total pancreatectomy alone

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Total Pancreatectomy and Islet Auto Transplantation for Chronic Pancreatitis

Surgical management of chronic pancreatitis is in a constant state of evolution. The trials of management are akin to the inherent complexity of the organ’s function and closeness to neighboring organs. As the progressive and irreversible process of chronic pancreatitis commences, patients are subjected to varying degrees of endocrine and exocrine loss, as well as pain. Management of this proce...

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Idiopathic hyperammonemia in a patient with total pancreatectomy and islet cell transplantation.

CONTEXT Idiopathic hyperammonemia is characterized by elevated serum ammonia associated with neurological deterioration of no other obvious etiology associated with relatively normal liver function tests and normal amino-acid levels. CASE REPORT We report a case of a 32-year-old woman who presented with acute mental status changes with a pelvic abscess approximately a year following her total...

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Total Pancreatectomy With Islet Cell Transplantation
for the Treatment of Pancreatic Cancer.

Resection or removal of the pancreas causes loss of parenchyma, which can result in extreme disruption of glucose homeostasis and malabsorption of dietary nutrients. However, islet autotransplantation (IAT) may reduce or prevent the severity of pancreatogenic diabetes. This article explores total pancreatectomy with IAT within the context of pancreatic cancer treatment. At a Glance • The liver ...

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Laparoscopic total pancreatectomy

RATIONALE Laparoscopic total pancreatectomy is a complicated surgical procedure and rarely been reported. This study was conducted to investigate the safety and feasibility of laparoscopic total pancreatectomy. PATIENTS AND METHODS Three patients underwent laparoscopic total pancreatectomy between May 2014 and August 2015. We reviewed their general demographic data, perioperative details, and...

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Vascularized islet cell transplantation in miniature Swine: islet-kidney allografts correct the diabetic hyperglycemia induced by total pancreatectomy.

We have previously reported the preparation of vascularized islet-kidneys (IKs) by transplantation of islets under the autologous kidney capsule. Here, we compare the efficacy of transplanting vascularized versus nonvascularized islets into diabetic allogeneic swine recipients. In the vascularized islet transplantation (5,000 islet equivalents [IE]/kg), recipients received minor-mismatched (n =...

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ژورنال

عنوان ژورنال: HPB

سال: 2014

ISSN: 1365-182X

DOI: 10.1111/hpb.12168